Let’s eat grandma

lets eat grandma cropped

Thinking about how to encapsulate alternative splicing in one ‘killer’ picture.

The picture above is what I came up with….

The analogy is that the inclusion/exclusion of alternative exons during pre-mRNA splicing can have the same dramatic effects as the inclusion/exclusion of key punctuation in a sentence.

I sincerely apologise to all Grandmas seeing/reading this….

Follow us on Twitter @SpliceTime

 

We are Detectorists

Screen Shot 2018-03-15 at 22.15.45

Loved the whimsical comedy of the ‘Detectorists‘ series with the excellent MacKenzie Crook (as Andy Stone) and Toby Jones (as Lance Stater). It follows Lance and Andy’s lives as their personal situations and ambitions orbit their central obsession with metal detecting.

It made me think of some analogies with Science. Obsession – yeah, tick. Do we ever stop thinking about our research topic? From hours of scanning the landscape only to uncover ‘ring-pull’ duds (yeah tick – see ‘failed experiments, no?). Or is it that we are just centimetres away from that Anglo-Saxon gold hoard.  Maybe we have selected the wrong ‘field’ in the first place. I think that, like Lance and Andy, most of us dream of landing ‘the big one’ –  maybe that discovery that will be transformative? We can but dream?

Especially loved the concept of the “discovery dance” – what kind of celebration would you do when the the game changing discovery comes your way….can you practice it? should you practice it?…or should it come as a natural reaction?

Here’s a link to a brief YouTube clip:

I think we are all Detectorists at heart. Think I’ll get practicing my dance….

Follow us on Twitter @SpliceTime.

Tubus Tubulus

 

tubes species cropped
Figure(d) Tubus sp. from left to right; Tubus grandis, T. eppendorfis, T. minieppendorfis, T. pcr spp. flatlid and T. pcr spp. roundlid. Botton right; aggregates of T. pcr

 

Just a bit of fun on this remarkable day – 1st April 2015 – the first description of some new lab species that show remarkable developmental plasticity…..

https://lopsidedlablife.wordpress.com/2015/04/01/innovations/

Follow us on Twitter @SpliceTime