I’ve been in Manchester this week attending the joint European Biological Rhythms Society (EBRS) and World Congress of Chronobiology (WCC). I presented a short communication entitled ‘An hnRNP isoform switch links temperature perception to regulation of the Arabidopsis circadian clock’. It was a wide and varied programme – although plant-clock research was thin on the ground (I was one of only two plant-clock presentations).
The highlight for me though was Michael Menaker’s plenary talk – the ‘grandfather’ of chronobiology research gave an overview of his journey through chronobiology research from when he was a graduate student in the USA the 1950’s. It was interested to hear him say how easy he felt it was to get funding back then – “…you would need to be a real idiot not to get a grant funded back then” and how the money sloshing about then was largely due to the space race. Another nugget of insight was “If you haven’t done any failed experiments, you haven’t tried hard enough”
Another quote that stuck with me was from Ueli Schibler’s Plenary lecture – the quote is, I think, attributed to Bertrand Russell – Mathematician/Philosopher/Writer and Nobel Laureate for Literature in 1950 – when he said “One of the symptoms of an approaching nervous breakdown is the belief that one’s work is terribly important”.
The RNA Journal is twenty years old and as part of their anniversary around 130 researchers in the field of RNA biology have contributed some of their personal reflections of working in this area. Contributors include Douglas Black, Michael Rosbash and Alberto Kornblihtt.
I’ve browsed through some of the essays and one that caught my attention was ‘Thoughts on NGS, alternative splicing and what we still need to know‘ by Kristen Lynch. Here she emphasises the need to determine the functional consequences of alternative splicing for an organism, and as she pointedly says ‘To truly appreciate the full impact of alternative splicing on biologic processes, and argue against those who wonder if it might all be “noise,” we need to do better. The question is how to achieve this goal’. [Note that NGS in the title of the article refers to Next Generation Sequencing]
As a relative newcomer to the field of AS, I think it’ll be useful for me to delve into these articles – they seem to be a refreshing way to learn how quickly research into AS has ‘evolved’ as well as providing an honest outlook as to what areas seem to be a priority for future work.
The cover art in interesting too – it is entitled ‘Group in Sea, 1979, by Philip Guston‘. He was an American abstract expressionist painter.
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